Partial Liquid Ventilation
Perfluorocarbons (PFC) are liquids of high density, low surface tension and good solubility for gases like oxygen and carbon dioxide. In medicine, they may be used for liquid ventilation. After filling the lung’s residual capacity (partial liquid ventilation, PLV) or the lung and the mechanical ventilator (total liquid ventilation, TLV) with PFC, appropriate gas exchange can be maintained. PFC is an optimal agent to re-open atelectases and is therefore studied in acute respiratory distress syndrome (ARDS) and other pulmonary diseases like meconium aspiration syndrome (MAS).
Our research centers on the effects of PFC on the surfactant system. We showed an anti-inflammatory effect of PFC and could prove that a mixture of PFC and surfactant is feasible and administrable. Furthermore, we work on the interactions of PLV and surfactant in systemic inflammation.
Wolfram Burkhardt, MD (senior research fellow)
Lars Mense, MD (research fellow)
Mense L, Rößler S, Hanusch R, Roßberg C, Rüdiger M. Bacterial Contamination of Mechanically Extracted Breast Milk. Am J Perinatol. 2013 Jun 13. read more...
Burkhardt W, Kraft S, Ochs M, Proquitté H, Mense L, Rüdiger M. Persurf, a new method to improve surfactant delivery: a study in surfactant depleted rats. PLoS ONE. 2012;7(10):e47923. doi:10.1371/journal.pone.0047923