Neonatal Research Group Dresden

The Role of Mesenchymal Stem- or Stromal Cells (MSCs) in Normal and Impaired Lung Development

 

Due to great improvements in perinatal medicine over the past decades, more and more extremely premature born babies survive the first critical days of life. Unfortunately, many of these newborns subsequently develop a severe lung disease named Bronchopulmonary Dysplasia (BPD); a condition characterized by an arrest in lung growth and maturation, affecting the whole children’s further development.

By now, many of the cellular mechanisms leading to the development of the disease are unknown. Also, there is no causal treatment; all current therapeutic approaches are preventive (reduction of ventilation, prevention of lung infections, proper nutrition of the newborn…) or supportive.

 

Recent studies in animal models of the disease show promising therapeutic potentials of exogenous Mesenchymal Stem- or Stromal Cells (MSCs), a cell type abundant in many connective tissues of the body. Also, recent findings suggest a role of the lung’s resident mesenchyme in the development of BPD. Working together with Prof. Bernard Thébaud, a neonatologist and clinician scientist at the Ottawa Hospital Research Institute, we try to understand role of the exogenous and resident lung MSCs in development and therapy of Bronchopulmonary Dysplasia.

Our aim is to identify the mechanisms by which these cells contribute to normal or impaired lung growth, thereby leading the way for first clinical trials in the near future.

 

Research is Teamwork. We are collaborating and working together with:

 

Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada

 

Children’s Hospital of New Mexico at the University of New Mexico, Albuquerque, New Mexico, USA

 

 

Publications:

 

Journal Papers: T.B.A.

 

Conference Proceedings:

 

“The Premature Human Fetal Lung Contains Mesenchymal Stromal Cells (MSCs) that Acquire an Deleterious Phenotype During Oxygen Exposure.”

Marius A. Möbius, Suzanne McConaghy, Robin K. Ohls, Farah Eaton, Shumei Zhong, Sarah Koss, Mario Rüdiger and Bernard Thébaud.

Poster, Annual Meeting of the Pediatric Academic Societies (PAS) 2013, Washington D.C., USA.

 

“Die Mesenchymalen Zellen der fetalen Lunge zeigen Charakteristika mesenchymaler Stamm- oder Stromazellen (MSCs).”

Marius A. Möbius, Suzanne McConaghy, Robin K. Ohls, Farah Eaton, Shumei Zhong, Mario Rüdiger and Bernard Thébaud.

Poster, 39. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI) 2013, Freiburg im Breisgau, Germany.

 

“Residente Mesenchymale Stamm- oder Stromalzellen der unreifen humanen Lunge (hFLMSCs) nehmen nach Sauerstoffexposition einen potentiell schädlichen Phenotyp an.”

Marius A. Möbius, Suzanne McConaghy, Robin K. Ohls, Farah Eaton, Shumei Zhong, Sarah Koss, Mario Rüdiger and Bernard Thébaud.

Oral Presentation, 39. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI) 2013, Freiburg im Breisgau, Germany.

 

 

“The Premature Human Fetal Lung Contains Mesenchymal Stromal Cells (MSCs) that Acquire an Deleterious Phenotype During Oxygen Exposure.”

Marius A. Möbius, Arul Vadivel, Sarah Koss, Shumei Zhong, Suzanne McConaghy, Robin K. Ohls, Mario Rüdiger and Bernard Thébaud.

Submitted Abstract, Till and McCulloch Meetings – Stem Cell Network Conference 2013, Banff, Alberta, Canada

 

 

 

©2013 Dimitrios Konstantelos